A recent pioneering technique, Long Range Cleavage sequencing (LORAX-seq), has been developed by researchers at NYU Langone Health to detect 'backtracking' events in the genetic material (genome) of various species. Backtracking, where RNA polymerase slips backward along the DNA chain during transcription, is a commonly occurring form of gene regulation. It happens frequently, persists longer than previously thought, and serves functions beyond DNA repair, potentially influencing gene expression and development. This research underscores its relevance in understanding diseases like cancer and aging, offering insights for potential therapeutic interventions.
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