Minnebio develops and manufactures enzymes, cytokine growth factors, and cell culture media for use in academic laboratory and pharmaceutical companies; and also provides services to develop and prepare customized proteins and cell culture media.
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Recombinant Human Interleukin-2

SKU:
$100.00
100 680 $100.00 - $680.00
Unavailable
per item
Products forms: Both liquid and lyophilized powder
Pack sizes: 100, 250, and 500 µg
Storage: 4 or -20 °C
Molecular weight: 15.4 kDa
Source: E Coli
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Human IL-2 (Accession ID: P60568) is a 15.4 kDa four-alpha-helix bundle cytokine with 133 amino acids. IL-2, produced by T cells during an immune response, was initially called T-cell growth factor. It stimulates growth and differentiation, and enhances function of T-cells, B-cells and natural killer (NK) cells. IL-2 has many immunostimulatory and immunoregulatory functions and has been shown to activate the cytotoxic function of natural killer (NK) cells, T lymphocytes, and monocytes, and to promote the cytotoxicity of these effector cells against a wide variety of neoplasms. The production of large quantities of purified recombinant IL-2 by expression from Escherichia coli greatly facilitated research to elucidate the biological roles of IL-2 in the immune system and enabled the use of IL-2 as a therapeutic medicine in the treatment of cancer. IL-2 activates and stimulates the growth of immune cells like T-Cells as well as Natural Killer Cells (NK Cells) for attacking cancer cells.


Applications:
  • The cultivation of human and murine IL-2 dependent T-cell lines and natural killer cell lines. 
  • The proliferation of mitogen-activated T-lymphocytes and natural killer cells.
  • Stimulating growth of T-cells and natural killer cells that participate in the pathogenesis of cancer and metabolic, infectious, autoimmune and inflammatory diseases. 
  • The activation of regulatory T cells to produce the cytokines tumor necrosis factor alpha (TNF-α) and interferon gamma (IFN-γ).

Technical notes:
  • Purity >98% by visualizing SDS-PAGE gel
  • Specific activity/EC 50: ≥2 x 106 IU/mg. The ED50 was determined by the dose-dependent stimulation of murine CTLL-2 cell proliferation.
  • Endotoxin ≤ 0.1 EU/ml by the LAL assay
  • Storage and Shipping: Stored in the PBS buffer. Upon arrival, keep the interleukin-2 in PBS buffer at 4°C and the lyophilized at -20 °C. Reconstitute the lyophilized Interleukin-2 in d H2O above 100µg/ml and further dilute to the final concentration.
  • Our IL-2 is 3 to 4-fold more effective than a brand product in the activation and stimulating growth of natural killer cells by cell proliferation assay.

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  • Home
  • Products
    • ​​PROTEINASE & PROTEASE >
      • Ultra-active Nuclease, Benzonase
      • Deoxyribonuclease 1
      • HRV 3C Protease
      • Protease K
    • Cytokine Growth Factor >
      • Fibroblast growth factor-2, FGF-2
      • Interleukin-2, IL-2
  • Lab Services
  • Advisor
  • About Us
  • Contact Us
  • Lab Supply